ABO Titers and Their Application

Please note: AABB reserves the right to make updates to this program.

Live Program: Wednesday, December 6, 2017 - On-Demand Available

Master Program Number: 17EL-159 (see program format numbers below under Registration)

Educational Track: Technical/Clinical
Topic: Transfusion Medicine
Intended Audience: Technologists, Apheresis Physicians and Nurses, Laboratory Staff, Medical Directors, Students/Fellows, Residents, Hospital Blood Banks, Immunohematology Reference Labs (IRL’s)
Teaching Level: Intermediate

Director: Geoffrey Wool, MD, PhD, Assistant Medical Director of Blood Bank, University of Chicago, Chicago, IL
Moderator: Kelly Meyer, Webcast Specialist, AABB, Bethesda, MD
Speakers: Tammy Gray, MLS (ASCP)CM, Medical Technologist Lead, University of Alabama at Birmingham Hospital, Birmingham, AL; Lawrence “Lance” A. Williams, III, MD, Medical Director, Coagulation Laboratory at UAB, Chief of Transfusion Services, Baptist Health System (Montgomery, AL) and Regional Medical Center (Anniston, AL), University of Alabama at Birmingham, Birmingham, AL

Learning Objectives

After participating in this educational activity, participants should be able to:

  • Describe ABO isohemagglutinin titer techniques and list their limitations.
  • Summarize the evolution of ABO incompatible renal transplant.
  • Discuss how apheresis removes ABO isohemagglutinins and how this relates to transfusion service.

Program Description

There are more than 99,000 patients on the U.S. waiting list for a kidney (UNOS 8/2016). Transplanting ABO incompatible kidneys offers recipients (particularly group O recipients) a significantly increased pool of potential kidneys. However, ABO incompatibility also has the potential to damage the allograft. In this program, the speakers will:

  • Review ABO isohemagglutinins and titer techniques
  • Discuss limitations of ABO isohemagglutinin titer performance
  • Review history of ABO incompatible (ABOi) renal transplant
  • Explain use of plasmapheresis in ABOi transplant patients
  • Examine case studies of ABO titration and their use in plasmapheresis cases
  • Discuss the future of transplant support for ABOi patients


   Program #
Single Viewer: On-Demand Register17EL-4035-159
Group Viewing: On-Demand Register17EL-8035-159

Speaker Biographies

Tammy Gray is an Auburn University graduate, with a B.S. degree in Medical Technology. She has been employed by the UAB Blood Bank since 2009. Tammy manages the education of all Blood Bank personnel.

Dr. Lawrence Williams, III is a board certified Clinical Pathologist at UAB. He completed his residency at East Carolina University, a Transfusion Medicine fellowship at Yale University, and a Hematopathology fellowship at Virginia Commonwealth University. After his training, he was offered a position at UAB in the Division of Laboratory Medicine. Dr. Williams is the Director of Coagulation at UAB and is the Chief of Transfusion Services for the Baptist Health System in Montgomery, Alabama and for Regional Medical Center in Anniston, Alabama. He is an integral part of the Apheresis Service at UAB and the Organ Transplant Service as an Apheresis physician.