Highs & Lows (and Everything In Between) Detection of Antibodies to High and Low-Incidence Antigens in Transfusion Medicine

Please note: AABB reserves the right to make updates to this program.

Live Program: Wednesday, March 7, 2018 - On-Demand Available

Master Program Number: 18EL-320 (see program format numbers below under Registration)

Educational Track: Technical/Clinical
Topic: Transfusion Medicine
Intended Audience: Hospital Blood Banks, Immunohematology Reference Labs (IRL’s), Laboratory Staff, Managers/Supervisors, Medical Directors, Physicians, Resident/Fellow, Students (MD, MT, SBB), Technologists, Transfusion Safety Officer
Teaching Level: Intermediate, Intermediate to Advanced

Director/Moderator: Isabella Martin, MD, Director of Clinical Microbiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH
Speaker: Amy Malmberg, MLS(ASCP)cm, Supervisor, Immunohematology Reference Lab, Blood Center of the Pacific, San Francisco, CA

Learning Objectives

After participating in this educational activity, participants should be able to:

  • Define and classify low-prevalence and high- prevalence antigens. Discuss their inheritance related to ethnicity.
  • Discuss the blood group systems/collections/series associated with commonly encountered antibodies to high and low-incidence antigens and their clinical significance.
  • Review the null phenotypes from each blood group system/collection/series that can guide in the identification of an unknown antibody.
  • Highlight strategies, explain special testing techniques, and offer tips for approaching identification and resolution of antibodies in these categories.
  • Provide transfusion recommendations in the management of patients with antibodies to high or low-prevalence antigens.

Program Description

This program will explore common situations in immunohematology that can complicate routine antibody screens: the detection and resolution of antibodies to high and low frequency antigens as well as HTLA-like (high titer, low avidity) antibodies.  The clinical significance of these types of antibodies, as well as testing strategies used for identification and resolution for each of these will be discussed.


   Program #
Single Viewer: On-Demand Register18EL-320-4035
Group Viewing: On-Demand Register18EL-320-8035

Continuing Education Credit

AABB designates both the live and on-demand version of this eCast each eligible for 1 continuing education credit/contact hour for Physicians, General Participation, California Nurse, California Lab Personnel and Florida Lab Personnel. The number and type of credits awarded for this program (both live and on-demand) was determined by the program duration. For more information on each credit type please visit our Continuing Education Credits webpage.

Disclosures for the planners of this event can be found here. Disclosures for the program faculty are provided at the beginning of the program.

Speaker Biography

Amy Malmberg, MLS(ASCP)cm is supervisor of the Immunohematology Reference Laboratory at the Blood Center of the Pacific, San Francisco, CA.  She obtained her Medical Laboratory Science degree, University of Cincinnati and is the former Vice President of the Minnesota Association of Blood Banks (MNABB).​