Cellular Therapies Subsections Projects

The subsections are composed of AABB members interested in common topics in the Cellular Therapies (CT) field. Member groups develop an array of ‘products’ in each area to serve as resources for other AABB members and CT professionals that include − but are not limited to− examples of procedures and templates, guidance documents, points to consider, troubleshooting tips, as well as presentations delivered by recognized experts.

New ideas are generated continuously and translated into useful tools which will be posted as they are completed.

To view the materials, simply click on the subsection name to see a listing of these resources.

Cord Blood

The Cord Blood Subsection develops resource materials that address a variety of issues related to this cell source.

Learning Tools

Umbilical Cord Blood Collection>

Presentations

Timing of CB Clamping - Its Impact on CB Collection PDF

CT Asia Pacific Group

The APG discusses topics and develops projects relevant to many of the subsection areas with emphasis on cord blood issues and potentially unique regional challenges.

Presentations

Regulation of Cell and Gene Therapy Products (PDF)
GMP Production of Pluripotent Stem Cell-Derived Therapeutics (PDF)
Building a New Processing Facility (PDF)
Therapeutic Neovascularization With Cell Transplantation - Limb-Cardiac Ischemia (PDF)
Clinical Trials: Moving Cell-Based Therapies to the Clinic (PDF)
ISBT 128: Overview and Implementation for Cellular Therapy (PDF)
How to Set Up a New Stem Cell Processing Laboratory (PDF)
Advances in Gene Therapy and Considerations for Blood Centers (PDF)
Adoptive Immunotherapy (PDF)
Clinical Translational of Vascular Niche for Hematopoietic Stem Cell Expansion and Transplant (PDF)

CT Current and Emerging Topics (CT-CET)

This subsection addresses topics surrounding the development and processing of cellular therapies including collection of cells from a variety of sources, manufacturing, testing, and strategies used in novel therapies and clinical practices.

Evaluation Tools

The resources listed below are intended as points to consider in evaluation of products and supplies in a systematic manner:
Validation Sample SOP (PDF)

Presentations

Sampling of presentations from invited experts:
cGMP Manufacturing for Cell Therapy (PDF)
Stem Cell Tourism (PDF)
Importance of Logistics in Cell Therapy Manufacturing (PDF)
Hematopoietic Chimerism - Present-Future Methods and Applications (PDF)
Implementation of Immune Effector Cell Therapy in Canada (PDF)
Stem Cells for Corneal Wound Healing (PDF)
Process Development Considerations for Cryopreservation of Cellular Therapies (PDF)
CT Translational Regenerative Rehabilitation Therapies (PDF)
Development - Validation of Rapid ALDH Bright-Based CB Potency Assay (PDF)
Human Platelet Lysate - Potential Uses (PDF)

Publications

Several members have published articles based on CT subsection activities:
Transfusion Practices for Bone Marrow Harvests: A Survey Analysis from the AABB Bone Marrow Quality Improvement Initiative Working Group
Use of Laboratory Tests to Guide Initiation of Autologous Hematopoietic Progenitor Cell Collection by Apheresis: Results from the Multicenter Hematopoietic Progenitor Cell Collection by Apheresis Laboratory Trigger Survey

Quality, Regulatory and Management Topics (QRM)

This subsection addresses regulatory issues, Guidance documents, quality program design, risk management, vendor and supply qualification, facility, environmental operational controls and how good management principles support these activities.

Presentations

Sampling of presentations from invited experts:
Blood Center Considerations for Product Collections, Processing and Distribution (PDF)

Management Tools

Service Level Agreement (PDF)

CT Spanish Language

The Spanish Language Subsection develops resource materials in Spanish that address cellular therapy issues.

Presentations

Herramienta de Auditoría ISBT 128 para Terapia Celular (PDF)