Immunohematology Boot Camp: Drug Induced Hemolytic Anemia (DIHA)

Please note: AABB reserves the right to make updates to this program.

Live Program: Wednesday, January 31, 2018 - On-Demand Available
Master Program Number: 18EL-305 (see program format numbers below under Registration)

Educational Track: Technical/Clinical
Topic: Transfusion Medicine
Intended Audience: Hospital Blood Banks, Immunohematology Reference Labs (IRL’s), Laboratory Staff, Managers/Supervisors, Medical Directors, Physicians, Resident/Fellow, Technologists, Transfusion Safety Officer
Teaching Level: Intermediate to Advanced

Director/Moderator: NurJehan Quraishy, MD, Assistant Medical Director, Transfusion Medicine, Cleveland Clinic, Cleveland, OH
Speakers: Waseem Anani, MD, Associate Medical Director, Blood Center of Wisconsin, Milwaukee, WI; Cindy Piefer MT(ASCP), SBB, Manager, Immunohematology Laboratory, Blood Center of Wisconsin, Milwaukee, WI

Learning Objectives

After participating in this educational activity, participants should be able to:

  • Discuss the mechanism of production of drug-induced antibodies and their serologic classification.
  • List some of the common drugs involved in DIHA.
  • Describe the immunohematologic findings in DIHA.
  • Discuss the special tests done at a reference laboratory for DIHA.
  • Discuss the clinical findings in patients with DIHA.

Program Description

Drug-induced immune hemolytic anemia (DIHA) is fortunately rare, but may be challenging for both the clinician and the blood bank. A high level of suspicion by the clinician may prompt the possibility of DIHA, however, serological testing is needed to confirm the diagnosis and often times, the blood bank raises concern for DIHA in a patient. This program will discuss the clinical and immunohematologic findings seen by a hospital blood bank which should raise concern for DIHA in a patient with immune hemolysis, and additional testing done by a reference laboratory. DIHA testing may mimic both warm and cold autoantibodies and an accurate patient history plays a key role in differential diagnosis.


   Program #
Single Viewer: On-Demand Register18EL-305-4035
Group Viewing: On-Demand Register18EL-305-8035

Continuing Education Credit

AABB designates both the live and on-demand version of this eCast each to be eligible for 1.0 continuing education credits/contact hours for Physicians, California Nurse, California Lab Personnel, Florida Lab Personnel and General Participation credit. The number and type of credits awarded for this program (both live and on-demand) was determined by the program duration. For more information on each credit type please visit our Continuing Education Credits webpage.

Disclosures for the planners of this event can be found here. Disclosures for the program faculty are provided at the beginning of the program.

Speaker Biographies

Dr. Waseem Anani is an Associate Medical Director at BloodCenter of Wisconsin. He primarily covers two large hospital systems and is a director-in-training for the Immunohematology Reference Laboratory. His research interests include the cross-section of molecular technologies and transfusion medicine and transfusion support of trauma patients.

Cindy Piefer has worked for The BloodCenter of Wisconsin for the past 19 years.  She started in the Transfusion Services lab and then transferred into the Immunohematology Reference Lab sixteen years ago.  Cindy obtained her SBB certification in 2002 and took on various roles in the reference lab to lead her to the manager role she is in today.​