Immunohematology Boot Camp Series: ABO/Le

Please note: AABB reserves the right to make updates to this program.

Live Program Date: Wednesday, May 29, 2019 – On-Demand Available

Master Program Number: 19EL-416 (see program format numbers below under Registration)

Educational Track: Technical/Clinical
Topic: Transfusion Medicine
Intended Audience: Facilities that perform molecular testing, Hospitals, Hospital Blood Banks, Immunohematology Reference Labs (IRL’s), Laboratory Staff, Medical Directors, Physicians, Resident/Fellows, Students (MD, MT, SBB), Technologists
Teaching Level: Intermediate

Director: Nancy M. Dunbar, MD, Associate Professor of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH
Moderator: April D. Hord, BB(ASCP)SBB, M.Ed., IRL Technical Trainer, American Red Cross, Richmond, VA
Speaker: Laura W. Cooling, MD, MSc, Associate Director, Blood Bank and Transfusion Services, University Hospital, Ann Arbor, MI

Learning Objectives

After participating in this educational activity, participants should be able to:

  • Recognize the molecular and biochemical basis for ABO and Lewis antigen expression.
  • Describe serological testing used to identify ABO and Lewis antibodies.
  • Explain the clinical significance of antibodies directed against the A, B, H, Lea and Leb antigens.
  • Name at least one disease association related to ABO and secretor status.

Program Description

The ABO system is the basis of pre-transfusion testing and blood compatibility. ABO is also a histocompatibility antigen important in organ transplantation. In many tissues, ABO interacts with the Lewis antigen synthesis, affecting the type of ABO and Lewis antigens found in plasma, epithelial cells and red cells. This interaction of ABO and Lewis plays a role in host susceptibility to many diseases. This program will review the serological, biochemical and molecular basis of ABO and Lewis antigen expression. In addition, the clinical significance of antibodies against these carbohydrate antigens will be contrasted.


   Program #
Single Viewer: On-Demand Register19EL-416-4035
Group Viewing: On-Demand Register19EL-416-8035

Continuing Education Credit

AABB designates both the live and on-demand version of this eCast each to be eligible for 1.0 continuing education credits/contact hours for Physicians, California Nurse, California Lab Personnel, Florida Lab Personnel and General Participation credit. The number and type of credits awarded for this program (both live and on-demand) was determined by the program duration. For more information on each credit type please visit our Continuing Education Credits webpage.

Disclosures for the planners of this event can be found here. Disclosures for the program faculty are provided at the beginning of the program.

Speaker Biography

Dr. Cooling received a B.S., a M.Sc. from the University of Iowa and an M.D. from the University of Iowa Medical School. She completed her residence training in Laboratory Medicine followed by a Fellowship in Transfusion Medicine and Pathology at the University of Iowa Hospitals and Clinics. Upon completion of her training, Dr. Cooling served as a Clinical Associate in the Department of Pathology at the University of Iowa Hospitals and Clinics and later as Assistant Professor at State University of New York Health Science Center at Syracuse. She joined the University of Michigan in 2000 and is currently a Professor in the division of Clinical Pathology. Dr. Cooling serves as Associate Director of Transfusion Medicine, the Director of the Immunohematology Reference Laboratory (IRL) and the Director, Cellular Therapy Laboratory (CTL). Dr. Cooling is board certified in Clinical Pathology and Blood Banking/Transfusion Medicine.