To Ignore or Not to Ignore? Transfusing Patients with Multiple Alloantibodies (21EL-612)

Please note: AABB reserves the right to make updates to this program.

Wednesday, March 10, 2021
2:00 – 3:00 PM Eastern Time
Program Number: 21EL-612

  • Educational Track: Technical/Clinical
  • Topics: Antibody Identification, Complications, Immunohematology, Patient Transfusion, Transfusion Process
  • Intended Audience: Directors, Hospital Blood Banks, Hospitals, Immunohematology Reference Labs (IRL’s), Laboratory Staff, Managers/Supervisors, Medical Directors, Nurses, Physicians, Residents/Fellows, Students (MD, MT, SBB), Technologists, Transfusion Safety Officers
  • Teaching Level: Basic, Intermediate
  • Director/Moderator: Lisa M. Shave MS, MLS(ASCP)CMSBBCM , Medical Laboratory Technology Program Coordinator & Professor, MLT Coordinator at Mercer County Community College, West Windsor, NJ, Blood Bank Medical Laboratory Scientist, MLS at Pennsylvania Hospital, Philadelphia, PA

    • Jeanne Hendrickson, MD, Professor of Laboratory Medicine; Medical Director of Apheresis Service/Laboratory Medicine; Associate Director, Transfusion Medicine Service, Yale University/Yale New Haven Hospital, New Haven, CT
    • Rebecca Ross, MA Ed, BS, MT (ASCP), SBB, Manager, Yale New Haven Blood Banks, Yale New Haven Hospital, New Haven, CT
    • Sean Stowell, MD, Associate Professor, Department of Pathology, Harvard University, Brigham and Women’s Hospital, Boston, MA
  • Program Description

    Red cell alloimmunization may occur during or after blood transfusions, evoking the immune system to produce alloantibodies. This program focuses on the induced response and reviews clinically significant versus clinically insignificant alloantibodies in patients who receive multiple transfusions with an emphasis on case examples.

    Learning Objectives

    After participating in this educational activity, participants should be able to:

    • Describe clinically significant antibodies.
    • Define antibodies that are clinically insignificant.
    • Discuss strategies to work through which antibodies may be transfused against in emergency situations.


    Registration includes access to both the live and on-demand version of this eCast.

    AABB understands the value of learning together as a group but with COVID-19, bringing everyone together to share the experience in person may not be an option for your team. Given this, all participants in a group will be provided the ability to register as a single viewer (AABB will provide a promocode to registered group viewing coordinators to share with their team in advance of the live program). If you are a facility interested in participating in this eCast, simply complete the Group Viewing registration form and AABB will provide detailed instructions to share with your team. For single viewers, the process has not changed – simply click on the Register button below to register.

    Please note: registration for the live eCast will close 1 hour prior to the eCast start time. If you register after this time you will receive access to the on-demand eCast when it is available.

    Single Viewer Register
    Group Viewing Register

    Continuing Education Credit

    AABB estimates both the live and on-demand version of this eCast each to be eligible for 1 continuing education credits/contact hours for Physicians, California Nurse, California Lab Personnel, Florida Lab Personnel and General Participation credit. The final number of credit(s) and credit types awarded for this program (live or on-demand) will be determined by the program duration. For more information on each credit type please visit our Continuing Education Credits webpage.

    Disclosures for the planners of this event can be found here. Disclosures for the program faculty are provided at the beginning of the program.

    Speaker Biographies

    Jeanne Hendrickson, MD is a pediatric hematologist and transfusion medicine specialist. Her clinical interests include factors influencing alloimmunization (particularly red blood cell alloimmunization), as well as strategies to minimize the formation and dangers of such antibodies. Her research interests include investigating the induction and consequences of red blood cell alloantibodies in transfusion and pregnancy situations, in murine models and in the clinical setting.

    Rebecca Ross, MA Ed, BS, MT (ASCP), SBB is the manager of the Yale New Haven Hospital Blood Banks. She has worked in laboratory medicine for many years, including the past 20 at Yale. In addition to having oversight of the blood banks, she teaches MLS students, clinical pathology residents, transfusion medicine fellows, hematology/oncology fellows, and others.

    Sean Stowell, MD is a clinical pathologist and immunologist, with interests in RBC alloantibodies, inhibitors to factor VIII, neonatal transfusion medicine, and glycobiology, among others. His translational research laboratory evaluates factors influencing RBC alloantibodies as well as the consequences of these antibodies.