CCP EAP Investigators Release Summary of Patient Characteristics
April 13, 2021
The Expanded Access Program (EAP)
for COVID-19 convalescent plasma (CCP) led by Mayo Clinic enrolled 105,717 hospitalized patients with severe or life-threatening COVID-19 between April 3 and Aug. 23, 2020, according to a summary of demographic and clinical patient characteristics published Sunday on the pre-print server medRxiv
Among all patients in the EAP, 57.8% were older than 60 years of age, 58.4% were male and 83.8% were overweight or obese. A total of 61.8% of enrolled patients had severe or life-threatening COVID-19, and 18.9% of patients were mechanically ventilated at the time of CCP infusion. Notably, the EAP included a substantial percentage of minority and underserved populations: 46.4% of patients were of a race other than white and 37.2% of patients were Hispanic. In addition, data showed that, chronologically and geographically, increases in EAP enrollment closely followed confirmed infection rates across all 50 states. Nearly all national hospital referral regions enrolled patients in the EAP.
According to investigators, the EAP’s study design may serve as an example framework for future efforts when broad access to treatment is needed in response to a disease affecting demographic groups and areas that have historically been underrepresented in clinical studies.