September 09, 2021
Moritz Stolla, MD, PhD, a 2018 recipient of a National Blood Foundation (NBF) early-career Scientific Research Grant, recently published research in Blood Advances that compared the function of cold-stored platelets and room temperature-stored platelets in vitro, in vivo and post-transfusion.
Stolla and his colleagues found that cold-stored platelets formed larger aggregates under in vitro shear while generating similar contractile forces compared to room temperature-stored platelets. They also found significantly reduced glycoprotein VI (GPVI) levels after cold exposure of 5-7 days.
Following transfusion in humans, cold-stored platelets were mostly equivalent to room temperature-stored platelets, but they aggregated significantly less to the GPVI agonist collagen. In a mouse model of platelet transfusion, cold-stored platelets had a significantly lower response to the GPVI-dependent agonist convulxin and lower GPVI levels on the surface.
Stolla and his colleagues concluded that the data suggest an immediate but short-lived benefit of cold-stored platelets and highlight the need for additional research in this area.
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