Latest Episode of Transfusion Monthly Podcast Focuses on TRALI and SD Plasma

Investigators from Amsterdam University Medical Center joined the latest episode of the Transfusion Monthly Podcast to discuss their recent research, which examined the incidence of transfusion-associated acute lung injury (TRALI) associated with solvent/detergent (SD) plasma in the Netherlands. In the Netherlands, approximately 55,000 units of solvent/detergent plasma are transfused each year.

In this study, Robert B. Klanderman, MD; Alexander P. J. Vlaar, MD, PhD, MBA; and their co-investigators reviewed pulmonary transfusion reactions involving SD plasma that were reported to the Dutch national hemovigilance network between 2016 and 2019. Of three imputable TRALI cases related to SD plasma, Klanderman, Vlaar and colleagues presented one case description of TRALI following SD plasma transfusion in a 69-year-old male. According to investigators, the findings demonstrated that TRALI can occur with SD plasma.

In a conversation with host Yara Park, MD, Klanderman and Vlaar provide a summary of their findings, describe the factors that inspired the study, and discuss how the hemovigilance system works in the Netherlands. They also explore what their findings may mean for clinicians who are administering SD and other plasma products.