Statistics and Study Design – What to Look for in a Manuscript and Innovative Approach to Clinical Trial Designs (22EL-742)

Please note: AABB reserves the right to make updates to this program.

• Educational Track: Scientific
• Topic: Patient Transfusion
• Intended Audience: CEOs, Directors, Hospital Blood Banks, Hospitals, Laboratory Staff, Managers/Supervisors, Medical Directors, Nurses, Perfusionists, Physicians, Research Scientists, Residents/Fellows, Scientists, Students (MD, MT, SBB), Technologists, Transfusion Safety Officers
• Teaching Level: Advanced, Intermediate

• Director/Moderator: Huy P. Pham, MD, MPH, Medical Director and Adjunct Professor of Medicine, National Marrow Donor Program (NMDP), Seattle, WA
  Speakers:

  • Richard Haspel, MD, PhD, Professor of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
  • Tuan V. Nguyen, DSc, PhD, Professor of Predictive Medicine, University of Technology Sydney (UTS), Australia; Professor of Epidemiology and Biostatistics, University of New South Wales (UNSW Sydney), Australia

• Program Description

  Improvements in the practice of medicine depends on the amount and quality of evidence, which in turn rely on the rigor of the research study design. Additionally, it is usually up to the clinicians to decide if a change in clinical practice is necessary after reading research reports, which may require both statistical and clinical knowledge. In this program, key considerations in study designs and statistical analysis as well as common pitfalls in result interpretation will be discussed. In Transfusion Medicine, traditional randomized controlled trials have been commonly used. However, in many cases, Bayesian approach to clinical trial design may offer better solution. Therefore, a summary of Bayesian approach to clinical design and interpretation will also be provided.

  Learning Objectives

  After participating in this educational activity, participants should be able to:

  • Discuss key considerations in statistics and study designs when reviewing a manuscript or publication.
  • Identify potential pitfalls in research study interpretations.
  • Describe the Bayesian approach to clinical trial design and interpretation.
  • Describe why clinical practice and Bayesian thinking are in tandem.

  Registration

  Registration includes access to both the live and on-demand version of this eCast.

  If you are a facility interested in participating in this eCast, simply complete the Group Viewing registration form and AABB will provide detailed instructions to share with your team approximately one week prior to the live program (each team member to register for the program utilizing a promocode). For single viewers, simply click on the Register button below to register.

  Please note: registration for the live eCast will close 1 hour prior to the eCast start time. If you register after this time you will receive access to the on-demand eCast when it is available.

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  Continuing Education Credit

  AABB estimates both the live and on-demand version of this eCast each to be eligible for 1.5 continuing education credits/contact hours for Physicians, California Nurse, California Lab Personnel, Florida Lab Personnel and General Participation credit. The final number of credit(s) and credit types awarded for this program (live or on-demand) will be determined by the program duration. For more information on each credit type please visit our Continuing Education Credits webpage.

  Disclosures for the planners of this event can be found here. Disclosures for the program faculty are provided at the beginning of the program.

  Speaker Biographies

  Dr. Haspel is currently the Medical Director of the Stem Cell Processing Laboratory and Vice Chair for Education in the Department of Pathology at Beth Israel Deaconess Medical Center (BIDMC). He is also a Professor of Pathology at Harvard Medical School. He developed and published a curriculum related to teaching evidence-based transfusion medicine. He has also led international studies to evaluate the transfusion medicine knowledge of internal medicine, pediatric and hematology physician trainees using a validated survey and exam.

  
  

  Dr. Nguyen is currently Director of Centre for Health Technologies and Professor of Predictive Medicine of UTS, and Conjoint Professor of the School of Population Health, UNSW Sydney. Apart from his primary research in osteoporosis, he has expertise in clinical trial design and large-scale epidemiological research. He is passionate about the application of Bayesian idea in the analysis and interpretation of clinical research. He has authored more than 320 peer-reviewed publications in mostly top tier journals, including Nature, Nature Genetics, BMJ, Lancet, and NEJM. He is among the world's most-cited researchers. He is an elected Fellow of the American Society for Bone and Mineral Research, and elected Fellow of the Australian Academy of Health and Medical Sciences.