Statistics and Study Design – What to Look for in a Manuscript and Innovative Approach to Clinical Trial Designs (22EL-742)

Please note: AABB reserves the right to make updates to this program.

• Educational Track: Scientific
• Topic: Patient Transfusion
• Intended Audience: CEOs, Directors, Hospital Blood Banks, Hospitals, Laboratory Staff, Managers/Supervisors, Medical Directors, Nurses, Perfusionists, Physicians, Research Scientists, Residents/Fellows, Scientists, Students (MD, MT, SBB), Technologists, Transfusion Safety Officers
• Teaching Level: Advanced, Intermediate

• Director/Moderator: Huy P. Pham, MD, MPH, Medical Director and Adjunct Professor of Medicine, National Marrow Donor Program (NMDP), Seattle, WA
  Speakers:

  • Richard Haspel, MD, PhD, Professor of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
  • Tuan V. Nguyen, DSc, PhD, Professor of Predictive Medicine, University of Technology Sydney (UTS), Australia; Professor of Epidemiology and Biostatistics, University of New South Wales (UNSW Sydney), Australia

• Program Description

  Improvements in the practice of medicine depends on the amount and quality of evidence, which in turn rely on the rigor of the research study design. Additionally, it is usually up to the clinicians to decide if a change in clinical practice is necessary after reading research reports, which may require both statistical and clinical knowledge. In this program, key considerations in study designs and statistical analysis as well as common pitfalls in result interpretation will be discussed. In Transfusion Medicine, traditional randomized controlled trials have been commonly used. However, in many cases, Bayesian approach to clinical trial design may offer better solution. Therefore, a summary of Bayesian approach to clinical design and interpretation will also be provided.

  Learning Objectives

  After participating in this educational activity, participants should be able to:

  • Discuss key considerations in statistics and study designs when reviewing a manuscript or publication.
  • Identify potential pitfalls in research study interpretations.
  • Describe the Bayesian approach to clinical trial design and interpretation.
  • Describe why clinical practice and Bayesian thinking are in tandem.

  Registration

  Please note: If you registered for the live eCast you do not need to register for the on-demand eCast (access to the on-demand eCast was included with the live eCast registration).

  Single Viewer	Register
  Group Viewing	Register

  Continuing Education Credit

  This activity is eligible for one and a half (1.5) continuing education credit/contact hour for Physicians, Nurses (including California-based nursing professionals through CBRN), California Lab Personnel, Florida Lab Personnel and General Participation credit. AABB reserves the right to reduce or increase the number of credits granted based on the final activity duration. For more information on each credit type please visit our Continuing Education Credits webpage.

  There is no financial support for this activity.

  

  In support of improving patient care, this activity has been planned and implemented by the Association for the Advancement of Blood & Biotherapies (AABB) and CME Outfitters, LLC. CME Outfitters LLC. is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

  Physicians (ACCME): CME Outfitters, LLC, designates this live activity for a maximum of one and a half (1.5) AMA PRA Category 1 Credit^TM. CME Outfitters, LLC, designates this enduring activity for a maximum of one and a half (1.5) AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  Claiming Credit
  Live Activity - Upon completion of the live activity, you will receive instructions to complete your evaluation, which is necessary to claim credit and receive your certificate of attendance/completion (credit must be claimed by the date provided in the instructions). The evaluation can be found by logging into the AABB Education Platform.

  Enduring Activity - Once the enduring (on-demand) program is available, you will receive instructions to access the AABB Education Platform. Upon completion of viewing the enduring activity, you will need to complete the evaluation, which is necessary to claim credit and receive your certificate of completion (credit must be claimed by the date provided in the AABB Education Platform).

  Program & Credit Expiration Dates:

  • Live Activity Program Date: June 15, 2022; Credit Expiration Date: July 15, 2022
  • Enduring Activity Program Dates: June 15, 2022 – June 14, 2025; Credit Expiration Date: June 14, 2025

  Disclosure Declaration

  It is the policy of CME Outfitters, LLC, and the Association for the Advancement of Blood & Biotherapies to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that the presence of such relationships will have a negative impact on the presentations.

  Disclosures for the planners of this event can be found here. Disclosures for the program faculty, peer reviewers, and CME Outfitters, LLC. personnel are provided at the beginning of the program.

  Speaker Biographies

  Dr. Haspel is currently the Medical Director of the Stem Cell Processing Laboratory and Vice Chair for Education in the Department of Pathology at Beth Israel Deaconess Medical Center (BIDMC). He is also a Professor of Pathology at Harvard Medical School. He developed and published a curriculum related to teaching evidence-based transfusion medicine. He has also led international studies to evaluate the transfusion medicine knowledge of internal medicine, pediatric and hematology physician trainees using a validated survey and exam.

  
  

  Dr. Nguyen is currently Director of Centre for Health Technologies and Professor of Predictive Medicine of UTS, and Conjoint Professor of the School of Population Health, UNSW Sydney. Apart from his primary research in osteoporosis, he has expertise in clinical trial design and large-scale epidemiological research. He is passionate about the application of Bayesian idea in the analysis and interpretation of clinical research. He has authored more than 320 peer-reviewed publications in mostly top tier journals, including Nature, Nature Genetics, BMJ, Lancet, and NEJM. He is among the world's most-cited researchers. He is an elected Fellow of the American Society for Bone and Mineral Research, and elected Fellow of the Australian Academy of Health and Medical Sciences.