Preparative Apheresis and Transfusion Support for Sickle Cell Disease Gene Therapy (25EL-527)

Please note: AABB reserves the right to make updates to this program.

• Educational Track: Technical/Clinical
• Topics: Blood Donation & Collection, Patient Transfusion
• Intended Audience: Hospitals, Immunohematology Reference Labs (IRL’s), Laboratory Staff, Managers/Supervisors, Medical Directors, Nurses, Physicians, Research Scientists, Residents/Fellows, Scientists, Students (MD, MT, SBB), Technologists, Transfusion Safety Officers
• Teaching Level: Advanced, Intermediate

• Director/Moderator: Elizabeth St. Lezin, MD, Clinical Professor of Laboratory Medicine Emeritus, UCSF, San Francisco, CA
  Speaker: John Manis, MD, Associate Professor Pathology, Harvard Medical School & Boston Children’s Hospital, Boston, MA

• Program Description

  For many patients with sickle cell disease (SCD), hematopoietic stem cell transplantation is unavailable due to lack of a matched donor. Gene therapy using autologous gene-edited stem cells has emerged as an option for these patients. Two gene therapy regimens have been approved by the FDA and additional clinical trials are underway. This program will provide background on gene therapy for SCD and an update on the status of SCD gene-editing clinical trials. The program will also address challenges in preparing products for patients enrolled in these trials and for the transfusion services providing transfusion support.

  Learning Objectives

  After participating in this educational activity, participants should be able to:

  • Demonstrate understanding of the role of gene therapy and gene-editing in the treatment of SCD.
  • Identify current FDA-approved gene therapy regimens and key gene-editing clinical trials in SCD.
  • Apply understanding of preparative transfusions for mobilization and collection of stem cells for SCD cell therapies.

  Registration

  Please note: registration for the live eCast is now closed. Registration is available for the on-demand eCast. If you registered for the live eCast you do not need to register for the on-demand eCast (access to the on-demand eCast was included with the live eCast registration).

  Single Viewer	Register
  Group Viewing	Register

  Continuing Education Credit

  This activity is eligible for one (1) continuing education credit/contact hour for Nurses (including California-based nursing professionals through CBRN), California Lab Personnel, Florida Lab Personnel and General Participation credit. AABB reserves the right to reduce or increase the number of credits granted based on the final activity duration. For more information on each credit type please visit our Continuing Education Credits webpage. Please note this program is not eligible for continuing medical education credit for physicians.

  There is no financial support for this activity.

  Claiming Credit
  Live Activity - Upon completion of the live activity, you will receive instructions to complete your evaluation, which is necessary to claim credit and receive your certificate of attendance/completion (credit must be claimed by the date provided in the instructions). The evaluation can be found by logging into the AABB Education Platform.

  Enduring Activity - Once the enduring (on-demand) program is available, you will receive instructions to access the AABB Education Platform. Upon completion of viewing the enduring activity, you will need to complete the evaluation, which is necessary to claim credit and receive your certificate of completion (credit must be claimed by the date provided in the AABB Education Platform).

  Program & Credit Expiration Dates:

  • Live Activity Program Date: April 23, 2025; Credit Expiration Date: May 23, 2025
  • Enduring Activity Program Dates: April 23, 2025 – April 22, 2028; Credit Expiration Date: April 22, 2028

  Disclosure Declaration

  Disclosures for the planners of this event can be found here. Disclosures for the program faculty and peer reviewers are provided at the beginning of the program.

  Faculty Biographies

  Dr. John Manis is an Associate Professor of Pathology at Harvard Medical School & Boston Children’s Hospital located in Boston, MA

  
  

  Dr. Elizabeth (Beth) St. Lezin is a Professor of Laboratory Medicine, Assistant Chief Laboratory Medicine and Director of Transfusion Service at the University of California San Francisco. Her research and clinical interests include clinical transfusion medicine, health and quality of life outcomes in red cell transfusion recipients, laboratory management and quality improvement in the clinical laboratory, and genetics of complex cardiovascular traits. Dr. St. Lezin has been the recipient of multiple awards including: Sudikow Award for Quality Improvement, UCSF/Mt. Zion Medical Center 1998; Laboratory Medicine Faculty Teaching Award 2016; and UCSF Center for Faculty Educators Certificate in Clinical Teaching 2018.