New CTMC Review Highlights Key Advances in Transfusion Medicine and Biotherapies From 2025

AABB’s Clinical Transfusion Medicine Committee (CTMC) has published its annual synopsis of key developments in transfusion medicine and biotherapies throughout the past year in Transfusion.

Published annually since 2018, the review compiles original research and major clinical practice guidelines selected by committee members for their importance, originality and potential to influence practice. For the 2025 review, members of the Biotherapies Leadership Committee joined the effort for the first time.

Highlights include new trial evidence on cord blood-derived red blood cells and cold-stored platelets, updated AABB and international platelet transfusion guidelines, donor screening changes tied to long-acting HIV prophylaxis, and the expansion of CAR-T and CAR-NK therapies into autoimmune disease.