New AABB Guide Addresses Advances in Prenatal and Postnatal Immunohematology Testing

November 22, 2023

AABB is pleased to announce the release of a new publication, the AABB Guide to Prenatal and Postnatal Immunohematology Testing, to promote shared understanding among professionals involved in formulating prenatal and perinatal testing practices. The new text is available in both print and digital formats in the AABB Store.

Historically, Rh(D) hemolytic disease of the fetus and newborn (HDFN) posed a significant threat to perinatal health. While the advent of neonatal exchange transfusion, intrauterine transfusion, amniocentesis, ultrasonography and Rh immunoglobulin (RhIG) prophylaxis have reduced the morbidity and mortality associated with Rh(D) HDFN, they have also resulted in a complicated landscape for managing prenatal and perinatal patients.

In this new publication, a team of expert authors lay a solid foundation on the fourfold objectives of prenatal and perinatal testing and discourage use of outdated, non-evidence-based practices and protocols. The guide provides a thorough exploration of the following key topics:

  • Routine testing during pregnancy, including purpose and timing.
  • Management of the alloimmunized patient, including those with different, non-Rh(D), alloantibodies that can cause HDFN.
  • Testing at delivery for both mother and neonate/cord blood.
  • Use of RhIG prophylaxis, including timing and dose.

To enhance accessibility and ease of comprehension, the guide presents its content in concise, tabular formats. It also navigates through controversial or inconclusive areas, presenting both sides of the argument and encouraging practitioners to remain updated on future advancements in the field.